This case study documents how the nutrition information systems in South Sudan, once weak and unreliable, have been transformed into a well-developed system supported by government, donors and Nutrition Cluster (NC) partners. It highlights how increased technical capacity in nutrition and information management within the Cluster Lead Agency (UNICEF) has allowed for the NC to focus on coordination. Integrating nutrition information management capacity into Ministry of Health (MoH) systems remains a work in progress. Summary: This case study underlines how the lack of nutrition coordination and information management capacity in conjunction with limited expertise of partners on the ground made it difficult to implement a comprehensive response, even though activities were costed in the response plan. It also highlights the lack of nutrition capacity to address nutrition issues beyond acute malnutrition in the Ukraine response, i.e. IYCF, Complementary Feeding, stunting and non-communicable diseases (NCD). In addition, there was a failure to programme for all vulnerable populations (i.e. older persons) or advocate across sectors and with local NGOs to consider nutrition as part of their responses.